In Vivo Biodistribution, Pharmacokinetics, and Toxicology of Carbon Nanotubes
Kai Yang and Zhuang Liu
Affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials, Soochow University, Suzhou, Jiangsu, 215123, China.
Owing to their interesting physical and chemical properties, carbon nanotubes (CNTs) have attracted wide attentions in
nanomedicine for applications in biological sensing, drug delivery, as well as biomedical imaging. The in vivo behaviors and toxicology
of CNTs in biological systems, which are important fundamental questions, although have been intensively studied in recent years, remain
to be clarified as distinctive results have been reported by various teams, confusing the scientific community as well as the public.
In this article, we review the research on the in vivo behaviors of CNTs, and summarize the toxicity studies of CNTs in animals by different
groups. Similar to other nanomaterials, the in vivo pharmacokinetics and biodistribution of CNTs are closely associated with their surface
coatings. The excretion of CNTs from animals may happen via renal and fecal pathways, depending on the CNT surface chemistry,
shape, and sizes. Regarding the toxicology of CNTs, which has been a debating topic for years, the administration routes, doses, and
again the surface functionalization are critical to the in vivo toxicity of nanotubes. Much more efforts are still required to develop functional
CNT bioconjugates with improved biocompatible coatings and controllable optimal sizes to achieve fast excretion and minimal
toxicity, for various applications in biomedicine.
Keywords: Carbon nanotubes, biodistribution, pharmacokinetics, toxicology, public health, nanotechnology, diagnosis
drugs, ullerene, cancer cells.
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