Fluorescent Carbon Dots and Nanodiamonds for Biological Imaging: Preparation, Application, Pharmacokinetics and Toxicity
Jia-Hui Liu, Sheng-Tao Yang, Xin-Xin Chen and Haifang Wang
Affiliation: Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China.
The rapid advancement of nanotechnology has brought us some new types of fluorescent probes, which are indispensable for
bioimaging in life sciences. Because of their innate biocompatibility, good resistance against photobleaching, long fluorescence lifetime
and wide fluorescence spectral region, fluorescent carbon quantum dots (C-Dots) and nanosized diamonds (nanodiamonds, NDs) are
gradually evolving into promising reagents for bioimaging. In this review, we summarize the recent achievements in fluorescent C-Dots
and NDs with emphases on their preparation, properties, imaging application, pharmacokinetics and toxicity. Perspectives on further investigations
and opportunities to develop C-Dots and NDs into the safer and more sensitive imaging probes for both living cells and animal
models are discussed.
Keywords: Carbon dots, fluorescent probe, nanodiamonds, pharmacokinetics, toxicity, Biological Imaging, Toxicity, quantum dots, fluorescent probes, biocompatibility, spectral region, NDs.
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