Fluorescent Carbon Dots and Nanodiamonds for Biological Imaging: Preparation, Application, Pharmacokinetics and Toxicity

Author(s): Jia-Hui Liu, Sheng-Tao Yang, Xin-Xin Chen, Haifang Wang.

Journal Name:Current Drug Metabolism

Volume 13 , Issue 8 , 2012

Abstract:

The rapid advancement of nanotechnology has brought us some new types of fluorescent probes, which are indispensable for bioimaging in life sciences. Because of their innate biocompatibility, good resistance against photobleaching, long fluorescence lifetime and wide fluorescence spectral region, fluorescent carbon quantum dots (C-Dots) and nanosized diamonds (nanodiamonds, NDs) are gradually evolving into promising reagents for bioimaging. In this review, we summarize the recent achievements in fluorescent C-Dots and NDs with emphases on their preparation, properties, imaging application, pharmacokinetics and toxicity. Perspectives on further investigations and opportunities to develop C-Dots and NDs into the safer and more sensitive imaging probes for both living cells and animal models are discussed.

Keywords: Carbon dots, fluorescent probe, nanodiamonds, pharmacokinetics, toxicity, Biological Imaging, Toxicity, quantum dots, fluorescent probes, biocompatibility, spectral region, NDs.

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2012
Page: [1046 - 1056]
Pages: 11
DOI: 10.2174/138920012802850083
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