Fullerenes for Cancer Diagnosis and Therapy: Preparation, Biological and Clinical Perspectives
Zhiyun Chen, Ruoqing Mao and Ying Liu
Affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No.11, 1st North Street, Zhongguancun, Beijing 100190, China.
Keywords: Fullerene, nanomaterials, cancer treatment, biological applications, Cancer, Diagnosis, METALLOFULLERENES, radiopharmaceuticals, vaporization, pharmacokinetics, lubricators, aromatic systems.
Cancer is a major public health problem in the world. There is a great need to apply novel technologies and drugs to revolutionize
multiple aspects of cancer diagnosis and therapy. Advances in nanotechnology and nanomaterials have the potential to achieve the
objective of early diagnosis and early therapy of cancer in the future. During the past few years, fullerene and its derivatives have been
considered as some of the most promising nanomaterials because of their unique properties that enable a variety of medicinal applications.
They can deliver drugs or small therapeutic molecules to the cancer cells. In this review, we will discuss how fullerene derivatives
have been introduced into the field of cancer diagnosis and therapy. It will be highlighted that fullerene derivatives are used as anti-tumor
drugs. Furthermore, preparation, characterization, pharmacokinetics and bio-distribution of fullerene and its derivatives reported in recent
years will be summarized.
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