“Click Chemistry” for Molecular Imaging

Author(s): Mengjing Wang , Yue Yuan , Gaolin Liang .

Journal Name: Current Molecular Imaging (Discontinued)

Volume 1 , Issue 1 , 2012

Abstract:

Click chemistry is a highly-selective and high-yield chemical approach which uses a wide scope of materials and does not call for purification. Molecular imaging is an in vivo characterization and measurement of biologic processes at the cellular and molecular level. Representative imaging modalities of molecular imaging are optical imaging, nuclear imaging, and magnetic resonance imaging (MRI). Up to date, click chemistry has been widely employed by molecular imaging to trap imaging probes on site and trace the biological events with high efficiency and high sensitivity. It has played an important role in early detection of disease, real-time monitoring of drug delivery and investigating the functions of biomolecules in vivo. Herein, we introduce the concept of click chemistry and illustrate the design of probes for molecular imaging based on the strategies of click chemistry.

Keywords: Click chemistry, molecular imaging, optical imaging, nuclear imaging, magnetic resonance imaging.

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2012
Page: [87 - 95]
Pages: 9
DOI: 10.2174/2211555211201010087

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PDF: 17