A rapid and efficient method for the synthesis of novel chenodeoxycholicacid acid thiosemicarbzones under
solvent-free conditions using microwave has been developed. Their structures were elucidated by ESI-MS, IR, 1H NMR
and elemental analysis. Nine novel compounds have been synthesized in good yields. Compared to the conventional
method, microwave irradiation method, main advantages are short reaction times, good conversions and the environmentally
friendly nature of the process. Preliminary results showed that some of these compounds possess inhibitory effects
against S. typhimurium and E. coli.
Keywords: Antibacterial activity, chenodeoxycholic acid, microwave irradiation, solvent-free, thiosemicarbazone, anti-tubercular, anti-tumor, anti-viral, anti-fungal, anticancer.
Rights & PermissionsPrintExport