22% Co/CeO2-ZrO2-catalyzed Synthesis of 1, 2, 3, 4-tetrahydro-2- pyrimidinones and -thiones

Author(s): Hajar Biklarian, Farahnaz K. Behbahani, Zahra Fakhroueian.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 8 , 2012

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Abstract:

Three-component condensation reaction of an aldehyde with β-ketoester and urea or thiourea in acetonitrile to afford the dihydropyrimidinones and thions (DHPMs) in the presence of 22% Co/CeO2-ZrO2 nano fine particle as a novel, reusable and green catalyst is reported. Utilizing of 22% Co/CeO2-ZrO2 nano fine particle catalyst also offers a cleaner process in that it can be reused and will not bring additional pollutants into the “environment” that is agreeable green chemistry point of view.

Keywords: 22% Co/CeO2-ZrO2, aldehydes, dihydropyrimidinones, 4-dihydropyrimidin-2, calcium, neuropeptide, thiones, HIV, anti-inflammatory, antihypertensive.

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Article Details

VOLUME: 9
ISSUE: 8
Year: 2012
Page: [580 - 584]
Pages: 5
DOI: 10.2174/157017812802850159
Price: $65

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