Three-component condensation reaction of an aldehyde with β-ketoester and urea or thiourea in acetonitrile to
afford the dihydropyrimidinones and thions (DHPMs) in the presence of 22% Co/CeO2-ZrO2 nano fine particle as a novel,
reusable and green catalyst is reported. Utilizing of 22% Co/CeO2-ZrO2 nano fine particle catalyst also offers a cleaner
process in that it can be reused and will not bring additional pollutants into the “environment” that is agreeable green
chemistry point of view.
Keywords: 22% Co/CeO2-ZrO2, aldehydes, dihydropyrimidinones, 4-dihydropyrimidin-2, calcium, neuropeptide, thiones, HIV, anti-inflammatory, antihypertensive.
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