The first efficient organocatalytic conjugate addition reaction of 2-arylacetates and 2-arylacetonitriles having
an electron-withdrawing group to nitroalkenes has been achieved using a bifuctional amino thiourea catalyst. The reagents
having NO2-, CO2Me-, and CN-functional groups on the aromatic ring can be used; the bifuctional catalyst 4i provided
Michael adducts in the reaction of various nitroalkenes with broad generality in high yield and diastereoselectivity.
Keywords: Bifuctional catalyst, conjugate addition, Michael addition, nitroalkene, organocatalysis, pronucleophiles, carbon, stereogenic, alkaloid, acetate.
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