The regioselective synthesis of the 3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)benzaldehyde as key
intermediate for divergent preparation of cytotoxic biaryl lignans was achieved in three steps from commercially available
starting materials. Reactivity of this synthon was illustrated by its conversion into the corresponding phenanthridine and
Keywords: Carbaldehydes, cytotoxic biaryls, lignans, phenanthridines, regioselective nitration, stille coupling, biphenyl, antitumor drugs, steganone, eupomatilone-6.
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