Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Adenovirus Vectors and Subviral Particles for Protein and Peptide Delivery

Author(s): Matthias W. Kron, Florian Kreppel.

Abstract:

Adenovirus vectors belong to the most frequently used vector type in gene therapy approaches. In addition, adenovirus vector particles and adenovirus subviral particles offer a great potential for the direct delivery of proteins into cells. In this review we discuss this potential and the technology of adenovirus as a protein delivery platform for applications ranging from vaccination to gene therapy.

Keywords: Protein delivery, adenovirus vector, adenovirus subviral particles, peptide delivery, gene transfer vectors, vector capsids, epidermal growth factor, endosomal

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2012
Page: [362 - 373]
Pages: 12
DOI: 10.2174/156652312802762563
Price: $58