Dermatological Treatments

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Dermatological treatments have changed continuously throughout recent decades. Old drugs are recognized as being effective in new indications and new methods of dosage or application have been ...
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Miscellanea: Antihistamines, Dapsone, Antimalarials

Pp. 403-433 (31)

Alejandro Fueyo-Casado

Abstract

In this chapter, three different drugs are resumed. Antihistamines are widely used in dermatological conditions to ameliorate pruritus and to inhibit the histamine release. Dapsone has been used for almost 50 years in the treatment of several infectious diseases including, leprosy and malaria and recently in the treatment of pneumocystic carinii pneumonia in patients with AIDS. Dapsone also has anti-inflammatory properties and has been used in dermatology and rheumatology. The development of the synthetic antimalarials and their use in the treatment of cutaneous diseases have been well described. Chloroquine is a 4-aminoquinoline antimalarial used in the treatment and prophylaxis of malaria. It has also been used in the treatment of hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Keywords:

Histamine antagonists, histamine H1 antagonists, histamine H1 antagonists, sedating, histamine H1 antagonists, non-sedating, dapsone, sulfones, antimlarials, antirheumatic agents, aminoquinolines, skin and connective tissue diseases, skin.

Affiliation:

Dermatology Department, Hospital Clínico San Carlos, Madrid, Spain