In the search of the sleep substance, many studies have been addressed for different hormones, responsible for
sleep-wake cycle regulation. In this article we mentioned the participation of steroid hormones, besides its role regulating
sexual behavior, they influence importantly in the sleep process. One of the clearest relationships are that estrogen and
progesterone have, that causing changes in sleep patterns associated with the hormonal cycles of women throughout life,
from puberty to menopause and specific periods such as pregnancy and the menstrual cycle, including being responsible
for some sleep disorders such as hypersomnia and insomnia. Another studied hormone is cortisol, a hormone released in
stressful situations, when an individual must react to an extraordinary demand that threatens their survival, but also known
as the hormone of awakening because the release peak occurs in the morning, although this may be altered in some sleep
disorders like insomnia and mood disorders. Furthermore neurosteroids such as pregnanolone, allopregnanolone and
pregnenolone are involved in the generation of slow wave sleep, the effect has been demonstrated in experimental animal
studies. Thus we see that the sleep and the endocrine system saved a bidirectional relationship in which depends on each
other to regulate different physiological processes including sleep.
Sleep, steroid hormones, endocrine system, cortisol, neurosteroids, ESTROGENS, Puberty, CORTISOL
Departamento de Biologia de la Reproduccion, Universidad Autonoma Metropolitana-Iztapalapa, C.P. 09340 Iztapalapa, D.F. Mexico, Mexico.