Resuscitation-promoting Factors (Rpf): In Search of Inhibitors

Author(s): Arseny S. Kaprelyants, Galina V. Mukamolova, Alessia Ruggiero, Vadim A. Makarov, Galina R. Demina, Margarita O. Shleeva, Vasilii D. Potapov, Pavel A. Shramko.

Journal Name: Protein & Peptide Letters

Volume 19 , Issue 10 , 2012

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Abstract:

Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity.

Keywords: Inhibitors, latency, nitrophenylthiocyanates, resuscitation, Rpf, tuberculosis, Mycobacterium tuberculosis, cell wall hydrolysing enzymes, therapeutic agents, molecular mechanisms

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Article Details

VOLUME: 19
ISSUE: 10
Year: 2012
Page: [1026 - 1034]
Pages: 9
DOI: 10.2174/092986612802762723

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