Synthesis and Antifungal Activity of 3-Substituted-thiochroman-4-one Semicarbazone Derivatives

Author(s): Hong-jian Geng, Zhao-bin Xing, Wei Luo, Ling Cong, Xin-yu Li, Chun Guo.

Journal Name: Letters in Drug Design & Discovery

Volume 9 , Issue 8 , 2012

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Abstract:

A series of 3-substituted-thiochroman-4-one semicarbazone derivatives were designed based on the bioisosterism and combination principle in drug design. The target compounds were prepared from 3-substitutedthiochroman- 4-one (1) and 4-substituted-semicarbazides( 2), their structures were confirmed by MS and 1H NMR. The antifungal assay was carried out in vitro by twofold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.

Keywords: 3-substituted-thiochroman-4-one semicarbazone, Synthesis, Antifungal activity, 4-substituted-semicarbazides, thiochromanones, semicarbazone, Fluconazole, fungal reproduction, thiochromanones moiety

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Article Details

VOLUME: 9
ISSUE: 8
Year: 2012
Page: [797 - 801]
Pages: 5
DOI: 10.2174/157018012802652903
Price: $58

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