A series of 3-substituted-thiochroman-4-one semicarbazone derivatives were designed based on the
bioisosterism and combination principle in drug design. The target compounds were prepared from 3-substitutedthiochroman-
4-one (1) and 4-substituted-semicarbazides( 2), their structures were confirmed by MS and 1H NMR. The
antifungal assay was carried out in vitro by twofold dilution. The result shows that all the compounds are of antifungal
activities against the tested fungi at different levels.
Keywords: 3-substituted-thiochroman-4-one semicarbazone, Synthesis, Antifungal activity, 4-substituted-semicarbazides, thiochromanones, semicarbazone, Fluconazole, fungal reproduction, thiochromanones moiety
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