Semi-Synthesis of Caudatin Glycosides and Study on their Antiproliferative Activities

Author(s): Xuefen Tao, Jin Chen, Rusong Zhang.

Journal Name: Letters in Drug Design & Discovery

Volume 9 , Issue 8 , 2012

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Four Caudatin glycosides were synthesized from Caudatin by reaction with tetra-O-actyl-D-glycosyl bromide catalyzed by CdCO3 and tested in vitro for their antiproliferative activities against human lung cancer A549, human prostate cancer PC3, human liver cancer BEL-7402 and human gastric cancer SGC-7901 cells. The IC50 values indicated that the inhibitory effect of Caudatin-tetra-O-actyl-D-glycosides was superior or comparable to Caudatin against most of the tested cells, worthy of further investigation.

Keywords: Antiproliferative activities, Caudatin, C21 steroidal glycosides, Glycosyl bromide, In vitro, Semi-Synthesis, Cynanchum auriculatum Royle ex Wight, 3β-hydroxyl group, aglycon, 14-O-isopropylidene-Caudatin (1)

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Article Details

Year: 2012
Page: [775 - 779]
Pages: 5
DOI: 10.2174/157018012802652985
Price: $58

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