Synthesis of Nimesulide Based New Class of Succinimide Analogues: Their Evaluation as Potential Cytotoxic Agents

Title:Synthesis of Nimesulide Based New Class of Succinimide Analogues: Their Evaluation as Potential Cytotoxic Agents

Volume: 9 Issue: 8

Author(s): Kavitha Kankanala, Vangala Ranga Reddy, Yumnam Priyadarshini Devi, Lakshmi Narasu Mangamoori, Khagga Mukkanti and Sarbani Pal

Affiliation:

Keywords: Nimesulide, Succinimide, Aza-Michael addition, Cancer, cytotoxic activities, N-arylsuccinamic acids, cytotoxic succinimide derivatives, N-aryl maleimide, Doxorubicin, acylhydrazides

Abstract: Novel succinimide derivatives based on nimesulide were designed as potential anticancer agents and their synthesis was carried out using a straightforward and atom economic method. The key step of this methodology involved an Aza-Michael addition of several nitrogen nucleophiles to the corresponding N-aryl maleimide derivatives prepared efficiently from nimesulide via a two-step process. A number of compounds containing –NHX (X = Ar, NHCOR, NHAr etc) at the C-3 of the succinimide were prepared in good yields. A number of compounds synthesized were tested for their cytotoxicity in vitro against human colon cancer cell lines and some of them showed promising activities.

Cite this article as:

Kankanala Kavitha, Ranga Reddy Vangala, Priyadarshini Devi Yumnam, Narasu Mangamoori Lakshmi, Mukkanti Khagga and Pal Sarbani, Synthesis of Nimesulide Based New Class of Succinimide Analogues: Their Evaluation as Potential Cytotoxic Agents, Letters in Drug Design & Discovery 2012; 9 (8) . https://dx.doi.org/10.2174/157018012802652921