A Triphenyltin(IV) Nicotinate Derivative – Synthesis and Toxicity Towards Different Tumour and Normal Cell Lines
Goran N. Kaluderovic.
[SnPh3(DMNI)] (1), (2,6-dimethoxynicotinic acid (DMNIH)) was prepared by the reaction of SnPh3Cl with
DMNIH. Molecular structure of 1 was determined by X-ray diffraction studies. The cytotoxic activity of 1 was tested
against tumour cell lines human cervical adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant
melanoma Fem-x and normal immunocompetent cells, non-stimulated peripheral blood mononuclear cells (PBMC-PHA)
and with phytohemagglutinin stimulated peripheral blood mononuclear cells (PBMC+PHA) showing a very high
antiproliferative activity against tumour cell lines with IC50 values (after 72 h of treatment) in the range of 46–65 nM. This
toxicity becomes lower against normal immunocompetent cells (IC50 values in the range of 88–148 nM) indicating some
degree of selectivity towards cancer cell lines.
Keywords: Anticancer drugs, Carboxylato ligands, Cytotoxicity, Metal-based drugs, Nicotinato ligands, Tin, phytohemagglutinin, antiproliferative activity, carboxylate derivatives, 2, 6-dimethoxynicotinic acid
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