A Triphenyltin(IV) Nicotinate Derivative – Synthesis and Toxicity Towards Different Tumour and Normal Cell Lines

Title:A Triphenyltin(IV) Nicotinate Derivative – Synthesis and Toxicity Towards Different Tumour and Normal Cell Lines

Volume: 9 Issue: 8

Author(s): Santiago Gomez-Ruiz, Zeljko Zizak and Goran N. Kaluderovic

Affiliation:

Keywords: Anticancer drugs, Carboxylato ligands, Cytotoxicity, Metal-based drugs, Nicotinato ligands, Tin, phytohemagglutinin, antiproliferative activity, carboxylate derivatives, 2, 6-dimethoxynicotinic acid

Abstract: [SnPh3(DMNI)] (1), (2,6-dimethoxynicotinic acid (DMNIH)) was prepared by the reaction of SnPh3Cl with DMNIH. Molecular structure of 1 was determined by X-ray diffraction studies. The cytotoxic activity of 1 was tested against tumour cell lines human cervical adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, non-stimulated peripheral blood mononuclear cells (PBMC-PHA) and with phytohemagglutinin stimulated peripheral blood mononuclear cells (PBMC+PHA) showing a very high antiproliferative activity against tumour cell lines with IC50 values (after 72 h of treatment) in the range of 46–65 nM. This toxicity becomes lower against normal immunocompetent cells (IC50 values in the range of 88–148 nM) indicating some degree of selectivity towards cancer cell lines.

Cite this article as:

Gomez-Ruiz Santiago, Zizak Zeljko and N. Kaluderovic Goran, A Triphenyltin(IV) Nicotinate Derivative – Synthesis and Toxicity Towards Different Tumour and Normal Cell Lines, Letters in Drug Design & Discovery 2012; 9 (8) . https://dx.doi.org/10.2174/157018012802652976