The growing perception that diseases are often consequences of multiple molecular abnormalities rather than being the result
of a single defect highlights the importance of network-centric view in therapeutic approaches. Protein interaction networks may contribute
to understanding of disease, assist in drug design and discovery. Here, we review some recent advances in disease-associated protein
interaction networks taking a structural approach. We first describe structural aspects of protein-protein interactions and properties of
protein interfaces as related to drug design; we address protein interactions in a network perspective; in particular, we illustrate how integrating
protein interfaces onto interaction networks can guide the identification of selective drug targets or drugs targeting multiple proteins
in a network.
Keywords: Protein-protein interfaces, protein interaction networks, drug design, drug targets, binding site, interfacial residues, transient, amino acid, Glycine, Cystine-Cystine.
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