Gambogic acid (GA) is a caged xanthone that is derived from Garcinia hanburyi and functions as a strong apoptotic inducer in
many types of cancer cells. The distinct effectiveness of GA has led to its characterization as a novel anti-cancer agent. There is an
increasing number of research studies focused on elucidating the molecular mechanisms of GA-induced anti-cancer effects, and several
critical signaling pathways have been reported to be influenced by GA treatment. In this review, we summarize the multiple functional
effects of GA administration in cancer cells including the induction of apoptosis, the inhibition of proliferation and the prevention of
cancer metastasis and tumor angiogenesis.
Keywords: Gambogic acid, Anti-cancer agents, Natural product, Apoptosis, Angiogenesis, Metastasis, pigment, glioblastoma, chemotherapeutic drugs, phosphorylation
Rights & PermissionsPrintExport