Diagnostic and Therapeutic Patents and Patent Applications on Biomarkers for Acute Kidney Injury
Acute kidney injury (AKI), a syndrome that is defined by a sudden and substantial decrease in kidney function,
can be caused by a variety of mechanisms including circulatory collapse, ischemia-reperfusion injury, systemic inflammatory
response, endogenous or exogenous toxicants or urinary obstruction. The causal and temporal sequence of kidney injury
leading to reduced function and in turn causing an increment in serum creatinine, however, hinders a timely detection
of this syndrome and may therefore also delay its early and effective treatment. In recent years, an increasing number of
promising biomarker candidates were described and patented to help in the detection, prognostic stratification and treatment
of AKI. The discovery and evaluation of novel biomarkers for AKI holds the promise to improve early detection and
allow for the development of effective treatments for this condition. This narrative review summarizes recent developments
in AKI biomarker patenting with a focus on both diagnosis and treatment-oriented patents and patent applications.
In addition, alternative methods for early detection of AKI, particularly patents and patent applications on continuous
urine output- and glomerular filtration rate monitoring, are presented and discussed in comparison. Finally, important potential
limitations for the application of biomarkers for AKI as well as alternative techniques for the measurement of kidney
function are discussed.
Keywords: Acute kidney injury, acute renal failure, biological markers, biomarkers, clinical research, diagnostics, patents, Urinary Biomarkers, Functional Kidney Markers, NGAL, GFR monitors.
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