Recent Software Developments and Applications in Functional Imaging
Lingfeng Wen, Stefan Eberl, Michael Fulham and (David) Dagan Feng
Affiliation: Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia.
Functional imaging allows the quantification of biochemical or biophysiological changes in-vivo through the
visualization of the spatial distribution and temporal changes of administrated radiopharmaceuticals. Instrumentation advances
such as PET-CT (positron emission tomography - computed tomography) and PET-MR (positron emission tomography
- magnetic resonance), improvements in image processing and reconstruction, the development of target and
disease-specific radiotracers and improved kinetic modelling techniques, have substantially enhanced our ability to measure
functional changes in normal and diseased states. Various combinations of these advances and refinements are now
used in routine clinical practice for patient care. In this paper we review recent literature on software developments and
applications in image restoration, motion correction, kinetic analysis, and image processing in the field of functional imaging.
Keywords: PET, SPECT, image correction, kinetic modelling, motion correction, PET-CT (positron emission tomography - computed tomography), PET-MR (positron emission tomography - magnetic resonance), disease-specific radiotracers, kinetic modelling techniques
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