Title:Patient-Specific Modeling and Multi-Scale Blood Simulation for Computational Hemodynamic Study on the Human Cerebrovascular System
VOLUME: 13 ISSUE: 11
Author(s):Marie Oshima, Ryo Torii, Shigefumi Tokuda, Shigeki Yamada and Akio Koizumi
Affiliation:Interfaculty Initiative in Information Studies / Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 163-8505 Japan.
Keywords:Patient-Specific Hemodynamic Computation, Three-Dimensional Vascular Modeling, Multi-Scale Simulation,
Cerebrovascular System, The Arterial Circle of Willis, drug delivery system, stroke, magnetic resonance imaging (MRI), computed tomography (CT) data, image-based three-dimensional simulation, multi-scale outflow
Abstract:To develop a targeted drug delivery system for cerebrovascular disorders such as stroke, it is important to obtain
detailed information on flow rates and hemodynamics of the human cerebrovascular system for individual patients. A
patient-specific integrated numerical simulation system has been developed by the authors such that vascular geometry is
constructed from medical images such as magnetic resonance imaging (MRI) or computed tomography (CT) data, and
computational conditions are modeled mathematically to represent the realistic in vivo environments. In general, the threedimensional
numerical simulation using a patient-specific model is conducted only for a localized diseased region with
atherosclerosis or an aneurysm. Although the analysis region is only a part of the circulatory system, the simulation should
include the effects from the entire circulatory system. Since the peripheral network determines the flow distributions in the
cerebrovascular system, the paper reviews the recent simulation methods to take into account the network by coupling the
image-based three-dimensional simulation with a one- and zero-dimensional simulations as an outflow boundary condition
The paper shows the mathematical modeling of the multi-scale outflow boundary condition and its applications to patient-
specific models of the arterial circle of Willis. The results are compared to those using the conventional, free-stream
boundary condition. As a result, the multi-scale outflow boundary condition shows a significant difference in flow rate of
each artery and in flow distribution in the arterial circle of Willis.
