Regenerative Treatment in Spinal Cord Injury
Spinal cord injury is a devastating, traumatic event, and experienced mainly among young people. Until the
modern era, spinal cord injury was so rapidly fatal that no seriously injured persons would survive long enough for regeneration
to occur. Treatment of spinal cord injury can be summarized as follows: prevent further cord injury, maintain
blood flow, relieve spinal cord compression, and provide secure vertebral stabilization so as to allow mobilization and rehabilitation,
none of which achieves functional recovery. Previous studies have focused on analyzing the pathogenesis of
secondary injury that extends from the injury epicenter to the periphery, as well as the tissue damage and neural cell death
associated with secondary injury. Now, there are hundreds of current experimental and clinical regenerative treatment
studies. One of the most popular treatment method is cell transplantation in injured spinal cord. For this purpose bone
marrow stromal cells, mononuclear stem cells, mesenchymal stem cells, embryonic stem cells, neural stem cells, and olfactory
ensheathing cells can be used. As a result, cell transplantation has become a promising therapeutic option for spinal
cord injury patients. In this paper we discuss the effectiveness of stem cell therapy in spinal cord injury.
Keywords: Cell transplantation, marrow stromal cells, mesenchymal stem cells, regeneration, spinal cord, stem cells, tissue
engineering, Spinal cord injury, Embryonic stem cells.
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