Abstract
Microtubules (MTs) are ubiquitous eukaryotic proteinaceous filaments showing a hollow cylindrical structure. MTs are composed of α-β-tubulin heterodimers arranged in linear protofilaments. MTs have a significant electric dipolar moment along their axes, which makes them capable of being aligned parallel to the applied electromagnetic field direction. Tubulin heterodimers were purified from rat brains. MTs were obtained by polymerization in vitro. Samples of microtubules adsorbed under and without electromagnetic fields with 500 Hz frequency. Our results demonstrate the effect of electromagnetic field with 500 Hz frequency to increase the polymerization of MTs. Some relevant patents are also outlined in this article.
Keywords: Electromagnetic field, microtubules, polymerization, rat brain.
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Title:Effect of Electromagnetic Field on the Polymerization of Microtubules Extracted from Rat Brain
Volume: 6 Issue: 3
Author(s): Mousavi Taghi, Riazi Gholamhosein and Rezayi-zarchi Saeed
Affiliation:
Keywords: Electromagnetic field, microtubules, polymerization, rat brain.
Abstract: Microtubules (MTs) are ubiquitous eukaryotic proteinaceous filaments showing a hollow cylindrical structure. MTs are composed of α-β-tubulin heterodimers arranged in linear protofilaments. MTs have a significant electric dipolar moment along their axes, which makes them capable of being aligned parallel to the applied electromagnetic field direction. Tubulin heterodimers were purified from rat brains. MTs were obtained by polymerization in vitro. Samples of microtubules adsorbed under and without electromagnetic fields with 500 Hz frequency. Our results demonstrate the effect of electromagnetic field with 500 Hz frequency to increase the polymerization of MTs. Some relevant patents are also outlined in this article.
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Cite this article as:
Taghi Mousavi, Gholamhosein Riazi and Saeed Rezayi-zarchi, Effect of Electromagnetic Field on the Polymerization of Microtubules Extracted from Rat Brain, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2012; 6 (3) . https://dx.doi.org/10.2174/187221412802481757
DOI https://dx.doi.org/10.2174/187221412802481757 |
Print ISSN 1872-2148 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3334 |
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