Abstract
The hypothalamus and posterior pituitary form a complex neurohumoral system playing a key role in maintaining body fluid homeostasis and reproductive function. We review the pathophysiology mechanisms of posterior pituitary hormones and their implications, beyond water balance and delivery, in social functioning, pair bonding and affiliative behavior. Actual and future treatments for neurohypophysis related disorders are also discussed, particularly focusing on the development of new therapeutic compounds and patents.
Keywords: Hypothalamus, neurohypophysis, oxytocin, pituitary, treatment, vasopressin.
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Title:The Hypothalamic-Neurohypophyseal System: Current and Future Treatment of Vasopressin and Oxytocyn Related Disorders
Volume: 6 Issue: 3
Author(s): Rocco S.Calabro, Domenico Italiano, Danilo Ferrara, Stefania Mondello, Valeria Conti-Nibali, Carlo Salviera and Placido Bramanti
Affiliation:
Keywords: Hypothalamus, neurohypophysis, oxytocin, pituitary, treatment, vasopressin.
Abstract: The hypothalamus and posterior pituitary form a complex neurohumoral system playing a key role in maintaining body fluid homeostasis and reproductive function. We review the pathophysiology mechanisms of posterior pituitary hormones and their implications, beyond water balance and delivery, in social functioning, pair bonding and affiliative behavior. Actual and future treatments for neurohypophysis related disorders are also discussed, particularly focusing on the development of new therapeutic compounds and patents.
Export Options
About this article
Cite this article as:
S.Calabro Rocco, Italiano Domenico, Ferrara Danilo, Mondello Stefania, Conti-Nibali Valeria, Salviera Carlo and Bramanti Placido, The Hypothalamic-Neurohypophyseal System: Current and Future Treatment of Vasopressin and Oxytocyn Related Disorders, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2012; 6 (3) . https://dx.doi.org/10.2174/187221412802481720
DOI https://dx.doi.org/10.2174/187221412802481720 |
Print ISSN 1872-2148 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3334 |
Related Articles
-
Autonomic Neural Functions in Space
Current Pharmaceutical Biotechnology Pharmacological Perspectives of Wasp Venom
Protein & Peptide Letters PPARγ Agonists: Beneficial Effect on Blood Pressure Beyond Glycemic Control?
Current Hypertension Reviews Pneumonia in the Elderly
Current Respiratory Medicine Reviews The Cardiotoxicity of Local Anesthetics: The Place of Ropivacaine
Current Topics in Medicinal Chemistry Neuronutrient Amino-Acid Therapy Protects Against Reward Deficiency Syndrome: Dopaminergic Key to Homeostasis and Neuroplasticity
Current Pharmaceutical Design Treatment of Catatonia with Asenapine in a Patient with Schizotypal Personality Disorder, Psychotic Depression and Septic Shock from SARSCoV- 2 - A Case Report
CNS & Neurological Disorders - Drug Targets Tolerability of Amine Uptake Inhibitors in Urologic Diseases
Current Drug Safety Fluorescein Fluorescence Use in the Management of Intracranial Neoplastic and Vascular Lesions: A Review and Report of a New Technique
Current Drug Discovery Technologies Toxic Shock Syndrome and Persistent Immune Activation in an HIVPositive Patient
Current HIV Research The Role of Pro-Inflammatory Molecules and Pharmacological Agents in Acute Pancreatitis and Sepsis
Inflammation & Allergy - Drug Targets (Discontinued) Angiotensin-(1-7): Blood, Heart, and Blood Vessels
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Respiratory Burns: A Clinical Review
Current Respiratory Medicine Reviews Fetal Undernutrition and the Programming of Blood Pressure
Current Nutrition & Food Science Scientific and Clinical Challenges in Sepsis
Current Pharmaceutical Design In Silico Studies Targeting G-protein Coupled Receptors for Drug Research Against Parkinson’s Disease
Current Neuropharmacology Ethyl Pyruvate: A Novel Treatment for Sepsis
Current Drug Targets Neurochemical and Neuropharmacological Aspects of Circadian Disruptions: An Introduction to Asynchronization
Current Neuropharmacology Kv1.5 Inhibitors for Treatment of Atrial Fibrillation: A Tradeoff between Selectivity and Non-selectivity
Current Topics in Medicinal Chemistry What have Genetically Engineered Mice Taught Us About Ischemic Injury?
Current Molecular Medicine