Molecular Imaging of Stem Cell Transplantation for Neurodegenerative Diseases
Ping Wang and Anna Moore
Affiliation: Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/ Harvard Medical School, Building 75, 13th Street, Charlestown, MA 02129, USA.
Cell replacement therapy with stem cells holds tremendous therapeutic potential for treating neurodegenerative diseases. Over
the last decade, molecular imaging techniques have proven to be of great value in tracking transplanted cells and assessing the therapeutic
efficacy. This current review summarizes the role and capabilities of different molecular imaging modalities including optical imaging,
nuclear imaging and magnetic resonance imaging in the field of stem cell therapy for neurodegenerative disorders. We discuss current
challenges and perspectives of these techniques and encompass updated information such as theranostic imaging and optogenetics in
stem cell-based treatment of neurodegenerative diseases.
Keywords: Molecular imaging, stem cells, neurodegenerative diseases, cell replacement therapy, optical imaging, optogenetics, fluorescence Imaging, bioluminescence Imaging, PET, SPECT
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