Anti-Irritants Agents for the Treatment of Irritant Contact Dermatitis: Clinical and Patent Perspective
Hongbo Zhai and Howard I. Maibach
Affiliation: Department of Dermatology, University of California, School of Medicine, Box 0989, Surge 110, 90 Medical Center Way, San Francisco, CA 94143-0989, USA.
Keywords: Barrier cream (BC), bioengineering, irritant contact dermatitis (ICD), moisturizers, occupational, prevention,
treatment, occupational dermatitis, Anti-irritants agents, Natural Anti-Irritant, Nonsteroidal Anti-Inflammatory Agents, Phosphodiesterase Inhibitors, Corticosteroids.
This overview defines whether anti-irritant agents, in fact, inhibit, prevent or treat irritant contact dermatitis
(ICD) in man. We performed a literature search using PubMed, EMBASE, and Scopus via the library at University of
California San Francisco, and a hand search of relevant text books to investigate chemicals that can be considered antiirritants
in either prevention or treatment. Emphasis was placed on data that included quantitative and qualitative results
and that followed evidence-based dermatological guidelines. Related patents were summarized. Conflicting observations
summarized here suggest well controlled, but often arduous, field type studies are required for confirmation.
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