Abstract
The endoplasmic reticulum (ER) is the site for maturation of proteins destined for the secretory pathway. Failure in maturation leads to production of misfolded proteins that are eliminated through the ER-associated degradation (ERAD) pathway. ERAD is a complex process that includes misfolded protein recognition, retrotranslocation to the cytosol, ubiquitination and proteasomal degradation. gp78 is an E3 ubiquitin ligase that integrates these ERAD steps by nucleating a unique degradation machine, which uses the p97/VCP-Npl4 complex for retrotranslocation instead of the wellknown p97/VCP-Ufd1-Npl4 complex. A growing list of substrates have been identified for gp78, which highlights the importance of gp78-mediated ERAD in essential physiological pathways and pathological processes.
Keywords: ubiquitination, retrotranslocation/dislocation, E3 ubiquitin ligase, gp78, Hrd1, p97/VCP, proteasome, endoplasmic reticulum, and ER-associated degradation
Current Protein & Peptide Science
Title:gp78: a Multifaceted Ubiquitin Ligase that Integrates a Unique Protein Degradation Pathway from the Endoplasmic Reticulum
Volume: 13 Issue: 5
Author(s): Zhiliang Chen, Shaojun Du and Shengyun Fang
Affiliation:
Keywords: ubiquitination, retrotranslocation/dislocation, E3 ubiquitin ligase, gp78, Hrd1, p97/VCP, proteasome, endoplasmic reticulum, and ER-associated degradation
Abstract: The endoplasmic reticulum (ER) is the site for maturation of proteins destined for the secretory pathway. Failure in maturation leads to production of misfolded proteins that are eliminated through the ER-associated degradation (ERAD) pathway. ERAD is a complex process that includes misfolded protein recognition, retrotranslocation to the cytosol, ubiquitination and proteasomal degradation. gp78 is an E3 ubiquitin ligase that integrates these ERAD steps by nucleating a unique degradation machine, which uses the p97/VCP-Npl4 complex for retrotranslocation instead of the wellknown p97/VCP-Ufd1-Npl4 complex. A growing list of substrates have been identified for gp78, which highlights the importance of gp78-mediated ERAD in essential physiological pathways and pathological processes.
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Cite this article as:
Chen Zhiliang, Du Shaojun and Fang Shengyun, gp78: a Multifaceted Ubiquitin Ligase that Integrates a Unique Protein Degradation Pathway from the Endoplasmic Reticulum, Current Protein & Peptide Science 2012; 13 (5) . https://dx.doi.org/10.2174/138920312802430590
DOI https://dx.doi.org/10.2174/138920312802430590 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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