Epidemiology of Type 2 Diabetes

Indexed in: Scopus

This e-book on diabetes epidemiology starts with the evolution in the diagnostic criteria for diabetes, particularly the changes in the last 15 years and their impact on the prevalence of the ...
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Uric Acid, Hyperuricemia and Diabetes

Pp. 82-97 (16)

Hairong Nan

Abstract

We began this chapter by summarizing the definition of hyperuricemia and its increasing prevalence in different ethnic groups that accompany the increase in obesity, diabetes and metabolic syndrome worldwide. This was followed by a discussion on complex associations between serum Uric Acid (UA) and Fasting and 2-hour Plasma Glucose (FPG and 2hPG) in both pre-diabetes and diabetic patients. The UA-glucose association was positive in the low FPG and low 2hPG distributions, but negative in the upper FPG and 2hPG distributions. In spite of inconsistent findings among studies, most prospective data found that higher levels of baseline UA predicted a future risk of developing type 2 diabetes independently. The direction of causality between value of UA and the development of type 2 diabetes is, however, uncertain. Further studies to investigate the pathophysiological mechanism underlying the relationship between glucose, UA and cardio-metabolic risk factors are gravely needed.

Keywords:

Diabetes and non-diabetic hyperglycemia, serum uric acid, hyperuricemia.

Affiliation:

Department of Community Medicine, School of Public Health, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China