Uric Acid, Hyperuricemia and Diabetes
Pp. 82-97 (16)
We began this chapter by summarizing the definition of hyperuricemia and its increasing
prevalence in different ethnic groups that accompany the increase in obesity, diabetes and metabolic
syndrome worldwide. This was followed by a discussion on complex associations between serum Uric
Acid (UA) and Fasting and 2-hour Plasma Glucose (FPG and 2hPG) in both pre-diabetes and diabetic
patients. The UA-glucose association was positive in the low FPG and low 2hPG distributions, but
negative in the upper FPG and 2hPG distributions. In spite of inconsistent findings among studies, most
prospective data found that higher levels of baseline UA predicted a future risk of developing type 2
diabetes independently. The direction of causality between value of UA and the development of type 2
diabetes is, however, uncertain. Further studies to investigate the pathophysiological mechanism
underlying the relationship between glucose, UA and cardio-metabolic risk factors are gravely needed.
Diabetes and non-diabetic hyperglycemia, serum uric acid, hyperuricemia.
Department of Community Medicine, School of Public Health, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China