Epidemiology of Type 2 Diabetes

Indexed in: Scopus

This e-book on diabetes epidemiology starts with the evolution in the diagnostic criteria for diabetes, particularly the changes in the last 15 years and their impact on the prevalence of the ...
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Lipid Levels and Glucose Intolerance

Pp. 65-81 (17)

Lei Zhang

Abstract

Dyslipidemia is one of the major risk factors for Cardiovascular Disease (CVD) that coexists with diabetes. It plays an important role in the development and progress of atherosclerosis, the underlying pathogenesis of CVD. Hyperglycemia is associated with adverse lipid profiles. An atherogenic lipid profile, consisting of high Triglycerides (TG) and small dense Low-Density Lipoprotein Cholesterol (LDL-C) and low High-Density Lipoprotein Cholesterol (HDL-C), is common not only in patients with overt diabetes but also in individuals with prediabetes. The impact of dyslipidemia on risk of CVD in patients with hyperglycemia has been extensively studied. Reduced HDL-C is well documented as an independent predictor of CVD events, the role of TG as an independent risk factor for CVD is, however, controversial. Recently, the interest to use novel parameters such as total cholesterol (TC) to HDL ratio (TC/HDL-C), non- HDL-cholesterol (non-HDL-C), apolipoprotein B (apoB) and apolipoprotein A (apoA) to assess CVD risk has increased. This chapter provides a comprehensive review of the physiology, pathophysiology, prognosis and management of dyslipidemia in individuals with different glycemic levels. The ethnic differences in occurrence of dyslipidemia are also addressed.

Keywords:

Lipid, glucose levels, cardiovascular mortality and mobidity, ethnicity.

Affiliation:

Department of Public Health, Hjelt Institute, University of Helsinki, PL41, Mannerheimintie 172, 00014, Helsinki, Finland and South Fuzhou Road 81, Qingdao Endocrine & Diabetes Hospital, 266071 Qingdao, China