On-Chip Pretreatment of Whole Blood by Using MEMS Technology

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The Microfabrication technology has stimulated a plurality of lab-on-a-chip research for biomedical researchers and health care practitioners to manipulate and analyze complex biological fluids at ...
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Integrated Microfluidic Chips for Whole Blood Pretreatment

Pp. 110-116 (7)

Xing Chen, Dafu Cui and Jian Chen

Abstract

Integrated on-chip whole blood sample pretreatment includes blood cell separation, cell lysis and DNA extraction. Compared to macro-counterparts, whole blood sample pretreatment using integrated microfluidic devices has the advantages of low sample consumption, short time-scale measurement and high portability. In this chapter, reported integrated microfluidic devices for blood sample preparation are briefly summarized and compared. And then a specific microfluidic chip with the function of cell separation, cell lysis and DNA extraction is proposed for detailed discussion. The integrated microfluidic device is capable of pre-treating whole blood samples, paving ways for the eventual integration of sample preparation, PCR, and electrophoresis on a single chip in the field of point-of-care genetic analysis, environmental testing, and biological warfare agent detection.

Keywords:

Integration, MEMS, microfluidics

Affiliation:

State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China