On-Chip Pretreatment of Whole Blood by Using MEMS Technology

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The Microfabrication technology has stimulated a plurality of lab-on-a-chip research for biomedical researchers and health care practitioners to manipulate and analyze complex biological fluids at ...
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Microfluidic Devices Targeting Blood Cell Lysis

Pp. 64-83 (20)

Xing Chen, Dafu Cui and Jian Chen

Abstract

Cell lysis is an essential step in whole blood sample preparation, which can pave road for intracellular proteomic analysis or genomic analysis and therefore cell membrane rupture is requested for protein and gene release. In this chapter, we firstly introduce reported microfluidic devices for cell lysis. And then an example using the chemical cell lysis method in microfluidic chip is put forward in which a sandwich microfluidic chip was designed, fabricated and tested to disrupt blood cell membranes.

Keywords:

Cell lysis, MEMS, microfluidics.

Affiliation:

State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China