Objective: To evaluate long-term outcomes in patients maintaining a nevirapine (NVP)-based regimen.
Methods: Retrospective, multicenter, cohort study including patients currently receiving an NVP regimen that had been
started at least 5 years previously. Demographic, clinical, and analytical variables were recorded.
Results: Median follow-up was 8.9 (5.7-11.3) years. Baseline characteristics: 74% men, 47 years old, 36% drug users,
40% AIDS, 40% HCV+, 51.4% detectable HIV-1 viral load, CD4 count 395 (4-1,421)/μL, 19% CD4 <200/μL, 27% ALT
grade 1-2, 36% AST grade 1-2. Thirty percent ART-naïve, 83% received NVP associated with 2 nucleoside analogues
during the study period, and 17% a protease inhibitor.
A significant improvement was observed in general health status markers, including hemoglobin, platelets, and albumin,
regardless of HCV coinfection. CD4 cell gain was +218 and +322/μL after 6 and 9 years, respectively (+321 and +391 in
naive patients). Triglycerides significantly decreased in pretreated patients, whereas the percentage of patients with HDLc
<1.03 mmol/L and LDL-c >3.37 mmol/L significantly decreased in a subsample with available values. A significant
decrease in transaminases, alkaline phosphatase, and Fib4 score was observed, mainly in HCV+ and ARV-naive patients.
Conclusions: In patients who tolerate NVP therapy, (even those with HCV coinfection), long term benefits may be
significant in terms of a progressive improvement in general health status markers and CD4 response, a favorable lipid
profile, and good liver tolerability.