Abstract
Condensation of 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with benzaldehydes under microwave irradiation gave chalcones or flavanones depending on the type of ketone. Also, 2-pyrazolines were synthesized by the condensation of chalcones with phenyl hydrazine under microwave irradiation in presence of dry acetic acid as a cyclizing agent. The results obtained indicated that, unlike classical heating, microwave irradiation resulted in higher yields, shorter reaction times and cleaner reactions. The structures of the synthesized compounds were elucidated using various spectroscopic methods. Theoretical studies explained the behaviour and reactivity observed for 1-acetyl-2-naphthol with benzaldehydes considering geometries, and electron densities of the formed flavanones.
Keywords: 1-Acetyl-2-naphthol, 2-Acetyl-1-naphthol, 2-Pyrazolines, chalcones, flavanones, microwave irradiation, anticancer, antinflammatory, antimalarial, anti-AIDS
Letters in Organic Chemistry
Title:Microwave–assisted Synthesis of Chalcones, Flavanones and 2- pyrazolines: Theoretical and Experimental Study
Volume: 9 Issue: 7
Author(s): Abdullah S. Al-Bogami
Affiliation:
Keywords: 1-Acetyl-2-naphthol, 2-Acetyl-1-naphthol, 2-Pyrazolines, chalcones, flavanones, microwave irradiation, anticancer, antinflammatory, antimalarial, anti-AIDS
Abstract: Condensation of 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with benzaldehydes under microwave irradiation gave chalcones or flavanones depending on the type of ketone. Also, 2-pyrazolines were synthesized by the condensation of chalcones with phenyl hydrazine under microwave irradiation in presence of dry acetic acid as a cyclizing agent. The results obtained indicated that, unlike classical heating, microwave irradiation resulted in higher yields, shorter reaction times and cleaner reactions. The structures of the synthesized compounds were elucidated using various spectroscopic methods. Theoretical studies explained the behaviour and reactivity observed for 1-acetyl-2-naphthol with benzaldehydes considering geometries, and electron densities of the formed flavanones.
Export Options
About this article
Cite this article as:
S. Al-Bogami Abdullah, Microwave–assisted Synthesis of Chalcones, Flavanones and 2- pyrazolines: Theoretical and Experimental Study, Letters in Organic Chemistry 2012; 9 (7) . https://dx.doi.org/10.2174/157017812802139609
DOI https://dx.doi.org/10.2174/157017812802139609 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
HMGB-1 as a Target for Inflammation Controlling
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Extraction, Isolation and Analysis of Chondroitin Sulfate Glycosaminoglycans
Recent Patents on Food, Nutrition & Agriculture Antioxidant and Cytotoxicity Activity of Phenolic Compounds from Piper sarmentosum Roxb. Against T47D Human Breast Cancer Cell
The Natural Products Journal Adverse Effects of Statins - Myths and Reality
Current Pharmaceutical Design Type 1 11 β-hydroxysteroid Dehydrogenase as Universal Drug Target in Metabolic Diseases?
Endocrine, Metabolic & Immune Disorders - Drug Targets PET/CT With 68Ga-PSMA in Prostate Cancer: Radiopharmaceutical Background and Clinical Implications
Current Radiopharmaceuticals Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy
Current Pharmaceutical Design Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy
Current Molecular Pharmacology The BCL2-Family of Protein Ligands as Cancer Drugs: The Next Generation of Therapeutics
Current Medicinal Chemistry - Anti-Cancer Agents Regulation of Adrenomedullin and its Family Peptide by RAMP System – Lessons from Genetically Engineered Mice
Current Protein & Peptide Science Impact of Renin-Angiotensin System in Hepatocellular Carcinoma
Current Cancer Drug Targets Kinetic Models for Measuring P-glycoprotein Function at the Blood-Brain Barrier with Positron Emission Tomography
Current Pharmaceutical Design Synthesis of bis(indolyl)methanes Using Naturally Occurring, Biodegradable Itaconic Acid as a Green and Reusable Catalyst
Current Organic Synthesis Autophagy as a Molecular Target of Flavonoids Underlying their Protective Effects in Human Disease
Current Medicinal Chemistry Specific Direct Small Molecule p300/β-Catenin Antagonists Maintain Stem Cell Potency
Current Molecular Pharmacology Modulation of Angiogenesis for Cancer Prevention: Strategies Based On Antioxidants and Copper Deficiency
Current Pharmaceutical Design Targeting Tumors Using Estrogen Receptor Ligand Conjugates
Current Cancer Drug Targets Drug Therapy of Neuropathic Pain: Current Developments and Future Perspectives
Current Drug Targets Natural and Synthetic Retinoids in Prostate Cancer
Current Pharmaceutical Design Targeting Role of Glioma Stem Cells for Glioblastoma Multiforme
Current Medicinal Chemistry