The preparation of substituted piperidines via three-component reaction between aldehydes, aromatic amines
and acetoacetic esters has been developed. The process has been carried out under ambient conditions in the presence of
zinc hydrogen sulfate [Zn(HSO4)2]. A variety of aldehydes and amines were yielded into the corresponding products
demonstrating the versatility of the reaction.
Keywords: Diastereoselectivity, functionalized piperidines, metal hydrogen sulfate, zinc hydrogen sulfate [Zn(HSO4)2], Donepezil, Sertindole, Risperidone, anti-inflammatory, anti-hypertensive, anti-convulsant
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