Zinc Hydrogen Sulfate Promoted Multi-component Preparation of Highly Functionalized Piperidines

Author(s): Majid Ghashang.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 7 , 2012

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Abstract:

The preparation of substituted piperidines via three-component reaction between aldehydes, aromatic amines and acetoacetic esters has been developed. The process has been carried out under ambient conditions in the presence of zinc hydrogen sulfate [Zn(HSO4)2]. A variety of aldehydes and amines were yielded into the corresponding products demonstrating the versatility of the reaction.

Keywords: Diastereoselectivity, functionalized piperidines, metal hydrogen sulfate, zinc hydrogen sulfate [Zn(HSO4)2], Donepezil, Sertindole, Risperidone, anti-inflammatory, anti-hypertensive, anti-convulsant

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Article Details

VOLUME: 9
ISSUE: 7
Year: 2012
Page: [497 - 502]
Pages: 6
DOI: 10.2174/157017812802139564

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