Micro-Flow Visualization of Magnetic Nanoparticles for Biomedical Applications
Pp. 600-612 (13)
R. Lima, R.J. Joseyphus, T. Ishikawa, Y. Imai and T. Yamaguchi
An investigation to measure the flow behavior of magnetic nanoparticles through
a 100μm microchannel is conducted. The magnetic field is applied externally by a
permanent magnet and by using a micro-PTV system it was possible to measure the flow
behavior of magnetic nanoparticles at different flow rates and magnetic fields through a
100μm glass capillary. A strong dependence on both magnetic and hydrodynamic force is
observed on the nanoparticles fluidic paths. Based on these in vitro studies, important
parameters and issues that require further understanding and investigation are point out.
Micro/nano flow, magnetic nanoparticles, superparamagnetism, Feoxide
layer, hyperthermia, microchannel, micro-PIV/PTV, glass capillary,
microcirculation, blood, physiological fluid, drug delivery, cancer therapy,
bioseparation, MRI contrast agent.
Department of Mechanical Technology, ESTiG, Bragança Polytechnic, C. Sta. Apolonia, 5301-857 Bragança, Portugal