Single and Two-Phase Flows on Chemical and Biomedical Engineering

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Single and two-phase flows are ubiquitous in most natural process and engineering systems. Examples of systems or process include, packed bed reactors, either single phase or multiphase, absorber and ...
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Micro-Flow Visualization of Magnetic Nanoparticles for Biomedical Applications

Pp. 600-612 (13)

R. Lima, R.J. Joseyphus, T. Ishikawa, Y. Imai and T. Yamaguchi


An investigation to measure the flow behavior of magnetic nanoparticles through a 100μm microchannel is conducted. The magnetic field is applied externally by a permanent magnet and by using a micro-PTV system it was possible to measure the flow behavior of magnetic nanoparticles at different flow rates and magnetic fields through a 100μm glass capillary. A strong dependence on both magnetic and hydrodynamic force is observed on the nanoparticles fluidic paths. Based on these in vitro studies, important parameters and issues that require further understanding and investigation are point out.


Micro/nano flow, magnetic nanoparticles, superparamagnetism, Feoxide layer, hyperthermia, microchannel, micro-PIV/PTV, glass capillary, microcirculation, blood, physiological fluid, drug delivery, cancer therapy, bioseparation, MRI contrast agent.


Department of Mechanical Technology, ESTiG, Bragança Polytechnic, C. Sta. Apolonia, 5301-857 Bragança, Portugal