Single and Two-Phase Flows on Chemical and Biomedical Engineering

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Single and two-phase flows are ubiquitous in most natural process and engineering systems. Examples of systems or process include, packed bed reactors, either single phase or multiphase, absorber and ...
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An-Harmonic Modeling of the Peripheral Distortion of the Arterial Pulse

Pp. 472-488 (17)

Panagiotes A. Voltairas, D.I. Fotiadis, A. Charalambopoulos and L.K Michalis


As blood circulates through the arterial tree, the flow and pressure pulse distort. Principal factors to this distortion are reflections from arterial bifurcations and the viscous character of the blood flow. Both of them are listed and expounded in the literature. Nevertheless, apart from direct numerical simulations, based on Navier-Stokes like equations, where the nonlinearities of inertial effects are taken into account, there isn’t any qualitative, as well as quantitative, analytical formula that explains their role in the distortion of the pulse. We derive an analytical quasi-linear formula, which emanates from a generalized Bernoulli’s equation for a linear viscoelastic flow in a quasi-elastic cylindrical vessel. We report that close to the heart (e.g., aortic arc), convection effects related to the change in the magnitude of the velocity of blood dominate the alteration of the shape of the pressure pulse, while at remote sites of the vascular tree, convection of vorticity, related to the change in the direction of the velocity of blood with respect to a mean axial flow, prevails. Comparison between the an-harmonic theory and related pressure measurements is also performed.


Arterial pulse, arterial pressure, flow pulse, pressure pulse, large blood vessels, blood flow, arterial pulse distortions, an-harmonic model, haemodynamic model, numerical simulations.


Department of Materials Science and Engineering, University of Ioannina, GR 451 10, Ioannina, Greece