Bone morphogenetic proteins (BMPs), members of the transforming growth factor Β (TGF-Β) superfamily, are
multifunctional secreted growth factors that are essential for coordinating complex developmental processes. Recent advances
using genetic and molecular approaches have recognized a previously underappreciated angiogenic role for BMP
signaling during vascular development and vascular disease. Compelling evidence includes the discovery of mutations in
BMP signaling components that have been found in patients with human hemorrhagic telangiectasia (HHT) and pulmonary
arterial hypertension (PAH). A comprehensive review of in vivo and in vitro studies has revealed that the angiogenic
response to BMP signaling is context and ligand dependent. This review provides details on these studies as the field
moves towards BMP-mediated therapeutic intervention of human vascular diseases.
Keywords: Bone Morphogenetic Protein, BMP signaling, angiogenesis, vascular development, HHT.
Rights & PermissionsPrintExport