Sonophoresis and Iontophoresis Mediated Transdermal Permeation of Prednisolone Acetate from Topical Hydrogels
Raghavendra V. Kulkarni, Ravindra P. Birajdar and Biswanath Sa
Affiliation: Department of Pharmaceutical Technology, BLDEA’s College of Pharmacy, BLDE University Campus, Bijapur 586 103, Karnataka, India.
In the present study, an attempt has been made to enhance the transdermal permeation of prednisolone acetate
through rat abdominal skin from topical hydrogel formulations with the help of sonophoresis and iontophoresis. The topical
hydrogels were prepared using sodium alginate and carbopol; further they were evaluated for drug content uniformity,
ex-vivo skin permeation with or without sonophoresis/iontophoresis and skin histopathology. Results reveal that under
iontophoretic and sonophoretic conditions, the drug permeation was enhanced 2-3 folds as compared to the drug permeation
under passive condition (without sonophoresis/iontophoresis). The presence of cineole enhanced the permeation of
drug under iontophoretic and sonophoretic conditions to a greater extent. The histopathological evaluation of skin suggests
that there were changes in the skin structure after application of ultrasound/DC electric current.
Keywords: Transdermal delivery, prednisolone acetate, sonophoresis, iontophoresis, penetration enhancer.
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