Pelletization by Extrusion Spheronization Technique: An Excipient Review
Namdeo Jadhav, Preeti Irny, Ashwini Mokashi, Pravin Souche and Anant Paradkar
Affiliation: Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Morewadi, Kolhapur-416013, Maharashtra, India.
Pellets/spheres have gained wide popularity amongst solid dosage forms due to numerous advantages offered
by their spheroid nature and each pellet acting as a seperate drug delivery device. At an industrial scale, pellets are manufactured
by extrusion-spheronization technique (ES) however, alternative techniques are also available. Such pellets obtained
may be used as neutral or drug loaded pellets. Till date, microcrystalline cellulose (MCC) was considered as a
golden standard for ES. Prior to MCC, sugar pareils were used as inert cores for drug loading. But due to physicochemical
interactions of MCC, and technological difficulties faced during processing of MCC and sugar pellets, the need for the
search of newer excipients as a pelletization aid has been triggered. To name a few, chitosan, carrageenan, starch, pectin,
talc etc are being explored. The present review is an attempt to take account of the excipients used to design multiple unit
particulate systems (MUPS) by ES technique and propose prospective excipient combinations to overcome limitations of
existing pellets and excipients thereof.
Keywords: Excipients, extrusion-spheronization, microcrystalline cellulose, pellets, pelletization techniques, prospective
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