Prospective and New Findings of Hydroxypropyl Methylcellulose (HPMC) as a Potential Carrier for Gastrorententive Drug Delivery Systems
Tapan Kumar Giri, Saurabh Verma, Ajazuddin, Amit Alexander, Hemant Badwaik and Dulal Krishna Tripathi
Affiliation: Rungta College of Pharmaceutical Sciences & Research, Kohka Road, Kurud, Bhilai-491024, India.
Gastroretentive drug delivery systems are able to prolong the overall gastric residence time and can improve
the oral bioavailability of the medicaments that show site specific absorption from the stomach or upper part of the small
intestine. Various approaches are currently utilized to retain the dosage form in the stomach including polymeric bioadhesive
systems, floating drug delivery systems, swelling and expanding systems, high density systems, biodegradable hydrogel
systems and other delayed gastric emptying devices. Among the numerous polymers that are being used for gastroretentive
drug delivery systems, hydroxylpropyl methyl cellulose (HPMC), possessing hydrophilic and gel forming
properties, is extremely advantageous. It is also nontoxic and biocompatible. In this article, the important properties of
HPMC and various techniques used for preparing gastroretentive dosage forms based on HPMC are reviewed. This review
also includes the investigation of various classes of drugs used for preparing HPMC based gastroretentive drug delivery
Keywords: Hydroxypropylmethylcellulose, Floating gastroretentive tablets, Controlled release, Bioadhesion, Capsules, Pellets.
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