Liposaccharides for Improved Oral Delivery of Tobramycin
Adel S. Abdelrahim, Pavla Simerska and Istvan Toth
Affiliation: University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, Queensland, Australia, 4072.
Many drugs have limited penetration through the gastrointestinal tract and therefore cannot be administered
orally. The aim of this study was to develop charged liposaccharide absorption enhancers to improve oral bioavailability
of model drug tobramycin. In vitro experiments, haemolysis, and cytotoxicity tests confirmed that the synthesized
liposaccharides were non-toxic at the concentrations used for oral administration. The partitioning coefficient of
tobramycin was improved to an acceptable range for oral delivery (log P = 1-3), when it was mixed with anionic
liposaccharides at molar ratio of 1:7.
Keywords: Charged liposaccharide, tobramycin, absorption enhancer, drug delivery.
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