Drug Delivery Letters

Marc Schneider  
Biopharmaceutics and Pharmaceutical Technology
Department of Pharmacy
Saarland University
661213 Saarbrücken
Germany

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Liposaccharides for Improved Oral Delivery of Tobramycin

Author(s): Adel S. Abdelrahim, Pavla Simerska and Istvan Toth

Affiliation: University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, Queensland, Australia, 4072.

Keywords: Charged liposaccharide, tobramycin, absorption enhancer, drug delivery.

Abstract:

Many drugs have limited penetration through the gastrointestinal tract and therefore cannot be administered orally. The aim of this study was to develop charged liposaccharide absorption enhancers to improve oral bioavailability of model drug tobramycin. In vitro experiments, haemolysis, and cytotoxicity tests confirmed that the synthesized liposaccharides were non-toxic at the concentrations used for oral administration. The partitioning coefficient of tobramycin was improved to an acceptable range for oral delivery (log P = 1-3), when it was mixed with anionic liposaccharides at molar ratio of 1:7.

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Article Details

VOLUME: 2
ISSUE: 2
Page: [92 - 97]
Pages: 6
DOI: 10.2174/2210304x11202020092