Drug Delivery Letters

Jia-You Fang  
Pharmaceutics Laboratory
Graduate Institute of Natural Products
Chang Gung University
Taoyuan
Taiwan

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Liposaccharides for Improved Oral Delivery of Tobramycin

Author(s): Adel S. Abdelrahim, Pavla Simerska, Istvan Toth.

Abstract:

Many drugs have limited penetration through the gastrointestinal tract and therefore cannot be administered orally. The aim of this study was to develop charged liposaccharide absorption enhancers to improve oral bioavailability of model drug tobramycin. In vitro experiments, haemolysis, and cytotoxicity tests confirmed that the synthesized liposaccharides were non-toxic at the concentrations used for oral administration. The partitioning coefficient of tobramycin was improved to an acceptable range for oral delivery (log P = 1-3), when it was mixed with anionic liposaccharides at molar ratio of 1:7.

Keywords: Charged liposaccharide, tobramycin, absorption enhancer, drug delivery.

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2012
Page: [92 - 97]
Pages: 6
DOI: 10.2174/2210304x11202020092
Price: $58