Spurred by remarkable findings in animal studies, there has been strong interest in evaluating the potential of
adult stem cells to improve left ventricular function in the past decade. Driven by the need to treat the increasing number
of patients with coronary artery disease, numerous studies have attempted to define a role for bone marrow cell therapy in
clinical use. However, the conflicting results of these studies can be confusing. This article will review the landmark trials
evaluating bone marrow cell therapy in the past decade and describe the current state of adult stem cell therapy and its future
Keywords: Bone marrow cell therapy, stem cell therapy, cardiac MRI, molecular imaging, human amniotic mesenchymal stem
cells, mesenchymal stem cells, paracrine effect.
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