A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%).
All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic
purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions,
inexpensive reagents, high yield and simple operation.
Keywords: Tasigna, Bcr-Abl kinase inhibitor, Facile synthesis, Cu-catalyzed N-arylation, Condensation, tyrosine kinase, tyrosine kinase, Palladium, Nickel, carbonyl chlorides
Rights & PermissionsPrintExport