A Novel and Facile Synthetic Approach for Tasigna

Author(s): Xiaoyan Pan , Wen Lu , Pengfei Li , Fang Wang , Chen Wang , Zhigang Hu , Jie Zhang .

Journal Name: Medicinal Chemistry

Volume 8 , Issue 5 , 2012

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Abstract:

A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.

Keywords: Tasigna, Bcr-Abl kinase inhibitor, Facile synthesis, Cu-catalyzed N-arylation, Condensation, tyrosine kinase, tyrosine kinase, Palladium, Nickel, carbonyl chlorides

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Article Details

VOLUME: 8
ISSUE: 5
Year: 2012
Page: [985 - 989]
Pages: 5
DOI: 10.2174/157340612802084207
Price: $58

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