Diet-derived natural ligands of the peroxisome proliferator-activated receptor (PPAR) family of nuclear
receptors have been widely reported to activate PPAR signaling, modifying gene and protein expressions in a variety of
cells and tissues. Examples of such dietary factors include unsaturated fatty acids, spices, soy protein, and polyphenols.
Recent data suggest that these nutrients may affect inflammation and immunity in arthritic diseases. This review describes
these nutrients and their potential modulating effects on the pathophysiology of inflammatory and degenerative arthritis
through PPAR signaling.
Keywords: Arthritis, diet, nutrient, PPARs, review.
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