Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents

Author(s): Silvia Franchini, Annalisa Tait, Claudia Sorbi, Livio Brasili.

Journal Name: Medicinal Chemistry

Volume 8 , Issue 5 , 2012

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Abstract:

A series of 1,3-oxathiolane-based nucleoside analogs 5-methyl substituted was synthesized and tested as potential antiviral agents. Structural characterization and C2-C4 / C2-C5 relative stereochemistry assignments were performed by NMR experiments. All tested isomers were found to be inactive and cytotoxic.

Keywords: 5-methyl-1, 3-oxathiolanes, Antiviral, NMR, Nucleosides, Stereochemistry, Synthesis, AIDS, RNA, DNA, drugs

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Article Details

VOLUME: 8
ISSUE: 5
Year: 2012
Page: [769 - 778]
Pages: 10
DOI: 10.2174/157340612802084162
Price: $58

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