TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases

Stella      Bernardi; Daniela      Milani; Bruno      Fabris; Paola      Secchiero; Giorgio      Zauli

Abstract

This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.

Keywords: Cardiovascular diseases, diabetes, TRAIL, Apo2 ligand, TNF, cellular apoptosis, OPG, coronary artery disease, biomarkers, soluble protein