Abstract
The blood-brain barrier (BBB) has been considered as an important regulator of brain homeostasis, and its disturbance has been implicated in the onset and/or evolution of many pathological manifestations of neurodegenerative and inflammatory diseases [1, 2]. In particular, BBB breakdown has been closely associated with the primary insult, as well as the secondary cell death of stroke. Here, we review the pioneering contributions of leading scientists who have vested interest in advancing our understanding of the pivotal role of BBB in stroke, but also exploiting this knowledge in developing novel BBB-based therapeutic regimens to abrogate stroke symptoms. The study of BBB as a fundamental research theme and as a target for clinical applications in stroke can be approached in three main themes namely, basic science research, translational and clinical research, and emerging therapies for BBB repair in stroke. This minireview captures cutting-edge discoveries establishing BBB as a central target for abetting neuroprotection and neurorestoration in stroke.
Keywords: Cerebral ischemia, central nervous system, permeability, bioavailability, pathology, therapy, blood-brain barrier (BBB), brain homeostasis, inflammatory diseases, stroke.
Current Pharmaceutical Design
Title:Breaking the Barrier in Stroke: What Should we Know? A Mini-Review
Volume: 18 Issue: 25
Author(s): Cesar V. Borlongan, Antonio A. Rodrigues and Maria Carolina Oliveira
Affiliation:
Keywords: Cerebral ischemia, central nervous system, permeability, bioavailability, pathology, therapy, blood-brain barrier (BBB), brain homeostasis, inflammatory diseases, stroke.
Abstract: The blood-brain barrier (BBB) has been considered as an important regulator of brain homeostasis, and its disturbance has been implicated in the onset and/or evolution of many pathological manifestations of neurodegenerative and inflammatory diseases [1, 2]. In particular, BBB breakdown has been closely associated with the primary insult, as well as the secondary cell death of stroke. Here, we review the pioneering contributions of leading scientists who have vested interest in advancing our understanding of the pivotal role of BBB in stroke, but also exploiting this knowledge in developing novel BBB-based therapeutic regimens to abrogate stroke symptoms. The study of BBB as a fundamental research theme and as a target for clinical applications in stroke can be approached in three main themes namely, basic science research, translational and clinical research, and emerging therapies for BBB repair in stroke. This minireview captures cutting-edge discoveries establishing BBB as a central target for abetting neuroprotection and neurorestoration in stroke.
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Cite this article as:
V. Borlongan Cesar, A. Rodrigues Antonio and Carolina Oliveira Maria, Breaking the Barrier in Stroke: What Should we Know? A Mini-Review, Current Pharmaceutical Design 2012; 18 (25) . https://dx.doi.org/10.2174/138161212802002670
DOI https://dx.doi.org/10.2174/138161212802002670 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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