Synthetic Approaches to 2-Arylbenzimidazoles: A Review

Author(s): Siva S. Panda, Ritu Malik, Subhash C. Jain.

Journal Name: Current Organic Chemistry

Volume 16 , Issue 16 , 2012

Abstract:

Benzimidazoles are very useful building blocks for the development of molecules that are important in medicinal chemistry. 2- Substituted benzimidazole derivatives have found applications as diverse therapeutic agents, including antiulcers, antihypertensives, antivirals, antifungals, anticancers, and antihistaminics. Because of their importance, the methods for their synthesis have become a focus of Synthetic Organic Chemists. However, we failed to locate report in the literature that covers various efforts that have been made for the synthesis of 2-arylbenzimidazoles. Therefore, in the present review, we have tried to compile some of the important synthetic techniques and methodologies used for its synthesis during the last decade.

Keywords: 2-Arylbenzimidazoles, Methodologies, Synthetic routes, o-phenylenediamine.

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Article Details

VOLUME: 16
ISSUE: 16
Year: 2012
Page: [1905 - 1919]
Pages: 15
DOI: 10.2174/138527212802651232
Price: $58

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