New Approaches to Nitrogen Containing Heterocycles: Enantioselective Organocatalyzed Synthesis of Dihydropyridines (DHP's), Quinolizidine Derivatives and Dihydropyrimidines (DHPM's)

Author(s): Hoai T. Pham, Isabelle Chataigner, Jean-Luc Renaud.

Journal Name: Current Organic Chemistry

Volume 16 , Issue 15 , 2012

Become EABM
Become Reviewer

Abstract:

Nitrogen-containing heterocycles, and more specifically the chiral ones, possess various biological and pharmaceutical properties. Among the approaches to these compounds, the organocatalyzed asymmetric multicomponent reaction has emerged as a powerful tool. This review will focus on the later development to chiral dihydropyridines, dihydropyrimidines and quinolizidines via asymmetric organocatalyzed synthesis....

Keywords: Dihydropyridines, Dihydropyrimidines, Quinolizidines, Chiral Brønsted acids, Chiral thioureas, Proline type derivatives, multicomponent condensation, cyclization, chiral pocket, Bronsted acids

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 16
ISSUE: 15
Year: 2012
Page: [1754 - 1775]
Pages: 22
DOI: 10.2174/138527212802651322

Article Metrics

PDF: 17